HOW THE WORLD GETS HIGH Get the Book
A Global Tour

Almost every branch of life on Earth has a gift that can and will change the human mind forever. Let’s unwrap those gifts together.

Sacred mushrooms, Amazon vines, mad honey, desert toads, and the science catching up to nine thousand years of practice.

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Kindle, paperback & hardcover · also in Kindle Unlimited
Any bookshop or library can order it — ISBN 979-8-9977099-0-7

How the World Gets High, by TJ Toce

The book travels by kingdom, not by country.

The book is your tour guide. These are the extra credit rooms you can wander off into and experience the wonders of nature.

FUNGI

A molecule perfectly shaped to fit a lock inside your head. Imagine that!

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CACTI

A sacred cactus that takes ten years to grow half an inch.

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VINES

Two plants that do nothing apart and everything together. Alchemy perhaps?

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AMPHIBIA

One little desert toad offers a vast dimensional gateway.

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FISH

A common fish creating a most uncommon experience.

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HONEY

It floored 10,000 Greek soldiers two millennia ago and is still for sale today.

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THE HUMAN BODY

An internal pharmacy built to expand consciousness.

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THE LAB

The synthetic path to enlightenment.

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9,000years since somebody painted a running man with mushrooms for arms
2,000votes. That's all Denver won by, and it started everything
80,000Amazonian species. They found the two that work together
1,000+papers on LSD published before it was banned in 1970
401BCE. Xenophon writes the first trip report in Western literature
5,700years ago, peyote in a Texas cave. Radiocarbon dated
9,000years since somebody painted a running man with mushrooms for arms
2,000votes. That's all Denver won by, and it started everything
80,000Amazonian species. They found the two that work together
1,000+papers on LSD published before it was banned in 1970
401BCE. Xenophon writes the first trip report in Western literature
5,700years ago, peyote in a Texas cave. Radiocarbon dated

What changed, and what only sounded like it did.

New every week. United States and international, kept honest and kept short.

Compass says it will file its psilocybin application within two weeks and still targets a launch in the first half of 2027

In its third-quarter results on November 3, Compass Pathways said the final submission of its new drug application for COMP360 in treatment-resistant depression is nearing completion and…

Compass Pathways (SEC filing) →

Psychedelic Alpha reports that Usona has completed its psilocybin application for depression

Psychedelic Alpha reported on November 2 that Usona Institute, a nonprofit, has completed a new drug application to the FDA for psilocybin in major depressive disorder. The report relies…

Psychedelic Alpha →

FDA approves NRx's preservative-free generic ketamine, while its bid to pull rival products stays pending

The FDA approved an abbreviated application from NRx Pharmaceuticals for a preservative-free ketamine, which the company has called KETAFREE. As a generic it carries the same label as…

Psychedelic Alpha →

Legalization, decriminalization and deprioritization are three different things — and almost every story you read confuses them.

What the words mean
THE
WEEKLY
NOTE
—
NO NOISE
The weekly note

The map gets redrawn most weeks, and most of what you read about it is wrong.

One short note a week when something real happens. Nothing at all when it does not. No digest, no roundup, no filler to justify the send.

No cost, no catch, and I will not sell your address to anybody, ever.